Avatrombopag-d8 hydrochloride
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Avatrombopag-d8 hydrochloride

Cat. No: CDIA-2237
Synonyms: AKR-501-d8 (hydrochloride); E5501-d8 (hydrochloride); YM477-d8 (hydrochloride)
Size: 500 mg
Price: Inquiry
Product Details
Formula C29H27D8Cl3N6O3S2
Molecular Weight 694.16
Smiles String O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5C([2H])([2H])C([2H])([2H])N(C6CCCCC6)C([2H])([2H])C5([2H])[2H])S3)=O)C=C2Cl)CC1)O.Cl
Storage & Handling
Shipping Room temperature.
Storage Please refer to the instruction manual.

Description

Avatrombopag-d8 (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.

! For research use only. Not intended for any clinical use.