Avanafil

Product Details
Formula	C23H26ClN7O3
Molecular Weight	483.95
Appearance	Solid
Purity	≥98.0%
Smiles String	COC1=C(Cl)C=C(CNC2=C(C(NCC3=NC=CC=N3)=O)C=NC(N4[[email protected]](CO)CCC4)=N2)C=C1

Storage & Handling
Shipping	Room temperature.
Storage Powder	-20 °C/3 years, 4 °C/2 years

Avanafil (TA-1790) is a potent and selective phosphodiesterase-5 (PDE-5) inhibitor with IC50 values of 5.2 nM, 630 nM, 5700 nM, 6200 nM, 12000 nM, 27000 nM, 51000 nM and 53000 nM for PDE-5, PDE-6, PDE-4, PDE-10, PDE-8, PDE-7, PDE-2 and PDE-1, respectively. Avanafil activates NO/cGMP/PKG signaling-pathway to decrease loss in BMD, bone atrophy, and oxidative stress. Avanafil inhibits cyclic guanosine monophosphate (cGMP) hydrolysis and thus increases cGMP levels. Avanafil can be used for the research of erectile dysfunction and osteoporosis.

! For research use only. Not intended for any clinical use.