AV123
Cat. No: CDIA-1981
CAS. No.: 233605-81-7
Size: 500 μg
Product Details |
Formula |
C11H14N4O2 |
Molecular Weight |
234.25 |
Smiles String |
O=[N+](C1=CC=C2C(NC(NCCCC)=N2)=C1)[O-] |
Storage & Handling |
Shipping |
Room temperature. |
Storage |
Please refer to the instruction manual. |
Description
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor (IC50=12.12 µM). AV123 blocks the TNF-α-induced necroptotic (EC50=1.7 μM) but not the apoptotic cell death. AV123 can be used in the study of necrotic chronic conditions such as ischemia-reperfusion injury of the brain, heart and kidney, inflammatory diseases, neurodegenerative diseases and infectious diseases.
! For research use only. Not intended for any clinical use.
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