APJ receptor agonist 4

Product Details
Formula	C28H28ClFN6O3
Molecular Weight	551.01
Smiles String	O=C1C(C(N2CC[[email protected]@H](C3=C(F)C=C(Cl)C=N3)C2)=O)=C(O)N(C4=C(CC)C=CC=C4CC)C(C5=NN(C)C=C5)=N1

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

APJ receptor agonist 4 is a potent and orally active agonist of apelin receptor (APJ) with EC50 and Ki of 0.06 nM and 0.07 nM respectively. APJ receptor agonist 4 displays excellent pharmacokinetic profiles in the rodent heart failure (HF) model. APJ receptor agonist 4 also shows an acceptable safety profile in preclinical toxicology studies. APJ receptor agonist 4 leads to improved cardiac function and can be used for researching the HF disease.

! For research use only. Not intended for any clinical use.