Angiotensin II, (human) TFA
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Angiotensin II, (human) TFA

Cat. No: CDIA-0739
CAS. No.: 2761969-44-0
Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA
Size: 10 mg
Price: Inquiry
Product Details
Formula C52H72F3N13O14
Molecular Weight 1160.20
Appearance Solid
Purity 99.49%
Sequence Shortening DRVYIHPF
Storage & Handling
Shipping Room temperature.
Storage Sealed storage, away from moisture and light, under nitrogen *In solvent : -80 °C, 6 months; -20 °C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Storage Powder -80 °C/2 years, -20 °C/1 year

Description

Angiotensin II human (Angiotensin II) TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Angiotensin II human TFA induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

! For research use only. Not intended for any clinical use.