(3R, 5R)-Rosuvastatin

Product Details
Formula	C22H28FN3O6S
Molecular Weight	481.54
Smiles String	O=C(O)C[[email protected]](O)C[[email protected]@H](O)/C=C/C1=C(C(C)C)N=C(N(C)S(=O)(C)=O)N=C1C2=CC=C(F)C=C2

Storage & Handling
Shipping	Room temperature.
Storage	Please refer to the instruction manual.

(3R,5R)-Rosuvastatin is the (3R,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC50 of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC50 of 195 nM. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels.

! For research use only. Not intended for any clinical use.